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Targeted Allele Detail
Symbol: Hba-xtm1Led
Name: hemoglobin X, alpha-like embryonic chain in Hba complex; targeted mutation 1, Philip Leder
MGI ID: MGI:2677497
Synonyms: zeta-, zeta-null
Gene: Hba-x  Location: Chr11:32276400-32278116 bp, + strand  Genetic Position: Chr11, 18.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:41934
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into the first exon of the gene. Northern blot analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript is expressed from this allele. (J:41934)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hba-x Mutation:  5 strains or lines available
Original:  J:41934 Leder A, et al., Mouse zeta- and alpha-globin genes: Embryonic survival, alpha-thalassemia, and genetic background effects. Blood. 1997 AUG 1;90(3):1275-1282
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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