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Targeted Allele Detail
Symbol: Irak4tm1Yeh
Name: interleukin-1 receptor-associated kinase 4; targeted mutation 1, Wen-Chen Yeh
MGI ID: MGI:2676448
Synonyms: IRAK-, Irak-4-, IRAK-4 KO
Gene: Irak4  Location: Chr15:94543613-94568317 bp, + strand  Genetic Position: Chr15, 48.55 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:76098
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2, which contains the start codon, was replaced with a neomycin selection cassette inserted by homologous recombination. Although mutant transcript was detected by RT-PCR analysis using C-terminal primers, neither normal nor truncated protein was undetected by Western blot analysis of MEFs derived from homozygous mutant mice. (J:76098)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irak4 Mutation:  3 strains or lines available
Original:  J:76098 Suzuki N, et al., Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 2002 Apr 18;416(6882):750-6
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory