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Targeted Allele Detail
Symbol: Fancatm1Wong
Name: Fanconi anemia, complementation group A; targeted mutation 1, Jasmine C Y Wong
MGI ID: MGI:2674094
Synonyms: Fancatm1Hsc
Gene: Fanca  Location: Chr8:123268300-123318576 bp, - strand  Genetic Position: Chr8, 72.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:85108
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 1 and all of exons 2 through 6 were replaced with a cassette containing IRES-NLS-lacZ and floxed neo. While transcript containing the targeted exons was undetected, RT-PCR analysis of homozygous mutant mice revealed transcript that included exons 14 through 18. A C-terminal antibody was not available to determine if protein was produced from the detected message. (J:85108)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fanca Mutation:  36 strains or lines available
Original:  J:85108 Wong JC, et al., Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum Mol Genet. 2003 Aug 15;12(16):2063-76
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
The Jackson Laboratory