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Targeted Allele Detail
Symbol: Rrm2btm1Ynak
Name: ribonucleotide reductase M2 B (TP53 inducible); targeted mutation 1, Yusuke Nakamura
MGI ID: MGI:2672883
Synonyms: Rrm2b-
Gene: Rrm2b  Location: Chr15:37923952-37961110 bp, - strand  Genetic Position: Chr15, 15.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:84841
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.4 kb genomic fragment encompassing exons 3 and 4 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of MEFs derived from homozygous mutant mice. (J:84841)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rrm2b Mutation:  16 strains or lines available
Original:  J:84841 Kimura T, et al., Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nat Genet. 2003 Aug;34(4):440-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory