Phenotypes associated with this allele

• Allele Symbol: Rrm2b^tm1Ynak
• Allele Name: targeted mutation 1, Yusuke Nakamura
• Allele ID: MGI:2672883
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rrm2b^tm1Ynak/Rrm2b^tm1Ynak	involves: 129 * C57BL/6J	MGI:2672952

Genotype
MGI:2672952

hm1

• Allelic Composition: Rrm2b^tm1Ynak/Rrm2b^tm1Ynak
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84841 )

• most mice died from severe kidney failure between 11 and 12 weeks of age

• no mice survived past 14 weeks of age

cardiovascular system

abnormal coronary artery morphology ( J:84841 )

• cornary artery contained hyaline deposits

cardiac fibrosis ( J:84841 )

• cardiac muscle appeared fibrotic

endocrine/exocrine glands

abnormal submandibular gland morphology ( J:84841 )

• submandibular gland was atrophic and had reduced numbers of secretory vesicles

thymus cortex hypoplasia ( J:84841 )

• reduced area containing lymphocytes

growth/size/body

postnatal growth retardation ( J:84841 )

• beginning at 6 weeks of age

hematopoietic system

thymus cortex hypoplasia ( J:84841 )

• reduced area containing lymphocytes

decreased spleen white pulp amount ( J:84841 )

• reduced area containing lymphocytes

homeostasis/metabolism

increased circulating creatinine level ( J:84841 )

• elevated creatine level

increased blood urea nitrogen level ( J:84841 )

• elevated blood urea nitrogen level

decreased circulating serum albumin level ( J:84841 )

• reduced concentration of albumin in the serum

increased urine protein level ( J:84841 )

• detectable as early as 4 weeks of age

immune system

thymus cortex hypoplasia ( J:84841 )

• reduced area containing lymphocytes

decreased spleen white pulp amount ( J:84841 )

• reduced area containing lymphocytes

abnormal mesenteric lymph node morphology ( J:84841 )

• reduced area containing lymphocytes

liver/biliary system

abnormal liver morphology ( J:84841 )

• hepatic tissue was atrophic around the central vein but normal around Grison's sheath

muscle

skeletal muscle atrophy ( J:84841 )

• skeletal muscle was systemically atrophic

renal/urinary system

increased urine protein level ( J:84841 )

• detectable as early as 4 weeks of age

glomerulosclerosis ( J:84841 )

dilated renal tubule ( J:84841 )

abnormal kidney physiology ( J:84841 )

• the spontaneous mutation frequency of the kidney was significantly higher than that of wild-type at 6 weeks of age, putatively due to attenuation of dNTP pools and a resulting impairment of DNA repair

increased kidney apoptosis ( J:84841 )

• increased apoptosis of renal cells

kidney failure ( J:84841 )

nervous system

abnormal sciatic nerve morphology ( J:84841 )

• vacuolations in sciatic nerve fibers

digestive/alimentary system

abnormal submandibular gland morphology ( J:84841 )

• submandibular gland was atrophic and had reduced numbers of secretory vesicles

cellular

increased kidney apoptosis ( J:84841 )

• increased apoptosis of renal cells