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Festm1Pag
Targeted Allele Detail
Nomenclature
Symbol: Festm1Pag
Name: feline sarcoma oncogene; targeted mutation 1, Peter A Greer
MGI ID: MGI:2670783
Synonyms: FesKR, fpsK588R, fpsKR
Gene: Fes  Location: Chr7:80377758-80387946 bp, - strand  Genetic Position: Chr7, 45.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84535
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsA dinucleotide substitution was introduced at codon 588 (exon 14), converting the lysine codon to an arginine codon. While protein was detected at wild-type levels in homozygous mutant mice, the absence of lysine 588, a conserved residue of the kinase subdomain II, resulted in an ablation of catalytic activity. The targeting construct also included neo and tk selection genes in the 3' untranslated region. (J:84535)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fes Mutation:  1 strain or line available
References
Original:  J:84535 Senis Y, et al., Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis. Mol Cell Biol. 1999 Nov;19(11):7436-46
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory