Fes^tm1Pag
Targeted Allele Detail

Summary

• Symbol: Fes^tm1Pag
• Name: feline sarcoma oncogene; targeted mutation 1, Peter A Greer
• MGI ID: MGI:2670783
• Synonyms: Fes^KR, fps^K588R, fps^KR
• Gene: Fes Location: Chr7:80027504-80037694 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Fes^tm1Pag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84535
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A dinucleotide substitution was introduced at codon 588 (exon 14), converting the lysine codon to an arginine codon (K588R). While protein was detected at wild-type levels in homozygous mutant mice, the absence of lysine 588, a conserved residue of the kinase subdomain II, resulted in an ablation of catalytic activity. The targeting construct also included neo and tk selection genes in the 3' untranslated region. (J:84535)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fes Mutation: 40 strains or lines available

References

• Original: J:84535 Senis Y, et al., Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis. Mol Cell Biol. 1999 Nov;19(11):7436-46
• All: 5 reference(s)