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Targeted Allele Detail
Symbol: Trove2tm1Woln
Name: TROVE domain family, member 2; targeted mutation 1, Sandra L Wolin
MGI ID: MGI:2670227
Synonyms: Ro-/-
Gene: Trove2  Location: Chr1:143750790-143777068 bp, - strand  Genetic Position: Chr1, 62.54 cM
Glomerulonephritis in Trove2tm1Woln/Trove2tm1Woln mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:84627
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetectable by Western blot analysis of homozygous mutant brain extracts. (J:84627)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trove2 Mutation:  4 strains or lines available
Original:  J:84627 Xue D, et al., A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7503-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory