Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ro60tm1Woln mutation
(0 available);
any
Ro60 mutation
(39 available)
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cellular
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• Background Sensitivity: significant increase in the number of apoptotic keratinocyte after exposure to UVB
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integument
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• Background Sensitivity: significant increase in the number of apoptotic keratinocyte after exposure to UVB, observed in mice that had been backcrossed to the C57BL/6 genetic background for 6 generations but not in mice that were on a mixed genetic background involving 129S1/Sv
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ro60tm1Woln mutation
(0 available);
any
Ro60 mutation
(39 available)
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Glomerulonephritis in Ro60tm1Woln/Ro60tm1Woln mice
mortality/aging
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• Background Sensitivity: approximately 28% mortality within 12 months of age, mixed genetic background involving 129S1/Sv and C57BL/6 but not when backcrossed to C57BL/6 background for 3 generations
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renal/urinary system
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• membranoproliferative glomerulonephritis observed in mice on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations
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immune system
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• 29-fold increase in unimmunized 8-week old mutants
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• 1.5-fold increase in in unimmunized 8-week old mutants
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• anti-chromatin and anti-ribosome antibodies were detected on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations
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• membranoproliferative glomerulonephritis observed in mice on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations
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integument
N |
• Background Sensitivity: keratinocytes from mice on a mixed 129S1/Sv and C57BL/6 background show similiar sensitivity to UVB exposure as wild-type mice compared to mutants backcrossed to C57BL/6 for 6 generations which show increased apoptosis
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hematopoietic system
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• 29-fold increase in unimmunized 8-week old mutants
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• 1.5-fold increase in in unimmunized 8-week old mutants
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Allelic Composition |
Ro60tm1Woln/Ro60+
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Genetic Background |
involves: 129S1/Sv * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ro60tm1Woln mutation
(0 available);
any
Ro60 mutation
(39 available)
|
|
|
immune system
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• 3-fold increase in unimmunized 8-week old mutants
|
|
• anti-chromatin and anti-ribosome antibodies were detected on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations
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hematopoietic system
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• 3-fold increase in unimmunized 8-week old mutants
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