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Itga2btm1(GFP/cre)Emam
Targeted Allele Detail
Nomenclature
Symbol: Itga2btm1(GFP/cre)Emam
Name: integrin alpha 2b; targeted mutation 1, Nikla R Emambokus
MGI ID: MGI:2670210
Synonyms: gpIIb-, gpIIbGFPCre
Gene: Itga2b  Location: Chr11:102453297-102469883 bp, - strand  Genetic Position: Chr11, 66.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84564
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Mutation detailsThe endogenous locus was disrupted by homologous recombination of a targeting vector containing sequence encoding a GFP-cre fusion protein followed by an FRT-flanked PGK-neo cassette. While expression of cre recombinase was detected in (and limited to) the megakaryocyte lineage by Western blot analysis, GFP fluorescence was not observed. Endogenous protein was undetected by either flow cytometry or Western blot analysis of homozygous mutant bone marrow cells. (J:84564)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Itga2b     Summary of all recombinase alleles driven by Itga2b.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga2b Mutation:  0 strains or lines available
References
Original:  J:84564 Emambokus NR, et al., The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Immunity. 2003 Jul;19(1):33-45
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory