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Skiltm2Spw
Targeted Allele Detail
Nomenclature
Symbol: Skiltm2Spw
Name: SKI-like; targeted mutation 2, Sonia Pearson-White
MGI ID: MGI:2670012
Synonyms: Snoex1-, SnoN-
Gene: Skil  Location: Chr3:31095058-31122577 bp, + strand  Genetic Position: Chr3, 15.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84554
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a lacZ gene together with a floxed neomycin gene construct. Full length mRNA transcript is reduced below detectable levels in homozygotes although truncated mRNA was produced. No full length protein from these mRNAs was detectable on immunoblots. (J:84554)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Skil Mutation:  18 strains or lines available
References
Original:  J:84554 Pearson-White S, et al., Defective T-cell activation is associated with augmented transforming growth factor Beta sensitivity in mice with mutations in the Sno gene. Mol Cell Biol. 2003 Aug;23(15):5446-59
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory