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Targeted Allele Detail
Symbol: Srsf3tm1Pjln
Name: serine and arginine-rich splicing factor 3; targeted mutation 1, Peter J Nielsen
MGI ID: MGI:2669749
Synonyms: p, SRp20p
Gene: Srsf3  Location: Chr17:29032660-29043372 bp, + strand  Genetic Position: Chr17, 15.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:57047
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP-flanked neomycin selection cassette was inserted into intron 1, and a single loxP site was inserted into intron 3 by homologous recombination. RT-PCR analysis of RNA derived from homozygous mice demonstrated that the insertions had no effect on the normal expression of the gene. (J:57047)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srsf3 Mutation:  23 strains or lines available
Original:  J:57047 Jumaa H, et al., Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20. Curr Biol. 1999 Aug 26;9(16):899-902
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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