Por^tm1Ding
Targeted Allele Detail

Summary

• Symbol: Por^tm1Ding
• Name: cytochrome p450 oxidoreductase; targeted mutation 1, Xinxin Ding
• MGI ID: MGI:2668450
• Synonyms: Cpr^lox
• Gene: Por Location: Chr5:135698894-135764180 bp, + strand Genetic Position: Chr5, 75.34 cM, cytoband G1
• Alliance: Por^tm1Ding page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84422
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 3 through 15 were flanked by single loxP sites located in introns 2 and 15. (J:85518)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Por Mutation: 78 strains or lines available

References

• Original: J:84422 Gu J, et al., Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem. 2003 Jul 11;278(28):25895-901
• All: 19 reference(s)