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Celsr1Crsh
Chemically induced Allele Detail
Nomenclature
Symbol: Celsr1Crsh
Name: cadherin, EGF LAG seven-pass G-type receptor 1; crash
MGI ID: MGI:2668337
Synonyms: MUT1494
Gene: Celsr1  Location: Chr15:85898758-86033777 bp, - strand  Genetic Position: Chr15, 40.42 cM
Mutation
origin
Strain of Origin:  (C3H/HeH x 101/H)F1
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsA A-to-G point mutation at nucleotide 3126 was induced by ENU mutagenesis. The mutation results in an aspartate to glycine substitution at codon 1040, which lies within the eighth cadherin repeat of the extracellular domain. Western blot analysis indicates no difference in abundance of protein. (J:84285, J:216413)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Celsr1 Mutation:  44 strains or lines available
References
Original:  J:84285 Curtin JA, et al., Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol. 2003 Jul 1;13(13):1129-33
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory