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Targeted Allele Detail
Symbol: Hivep3tm1Lcw
Name: human immunodeficiency virus type I enhancer binding protein 3; targeted mutation 1, Lai-Chu Wu
MGI ID: MGI:2667235
Synonyms: KRC-
Gene: Hivep3  Location: Chr4:119733784-120138045 bp, + strand  Genetic Position: Chr4, 55.51 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:266689
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 486 bp fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region corresponded to nucleotides 954 through 1440 of the cDNA and encoded the first zinc finger pairs. The insertion of the cassette was reported to disrupt the open reading frame at codon 99. Protein was undetected by Western blot analysis of homozygous mutant mice. (J:79652)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hivep3 Mutation:  21 strains or lines available
J:79652 reports the phenotypic analysis of chimeric mice made by injecting Hivep3-/- ES cells into Rag2-/- blastocyts. The chimeras were estimated to be composed of greater than 50% Hivep3tm1Lcw/Hivep3tm1Lcw derived cells.
Original:  J:79652 Allen CE, et al., Developmental anomalies and neoplasia in animals and cells deficient in the large zinc finger protein KRC. Genes Chromosomes Cancer. 2002 Dec;35(4):287-98
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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