Phenotypes associated with this allele

• Allele Symbol: Hivep3^tm1Lcw
• Allele Name: targeted mutation 1, Lai-Chu Wu
• Allele ID: MGI:2667235
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hivep3^tm1Lcw/Hivep3^tm1Lcw	chimera involves: 129S/SvEv * 129X1/SvJ	MGI:3815548

Genotype
MGI:3815548

hm1

• Allelic Composition: Hivep3^tm1Lcw/Hivep3^tm1Lcw
• Genetic Background: chimera involves: 129S/SvEv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased double-positive T cell number ( J:79652 )

• in a Rag2-deficient blastocyst complementation experiment, chimeras show decreased numbers of CD4+CD8+ thymocytes by 6 months of age

neoplasm

increased teratoma incidence ( J:79652 )

• in a Rag2-deficient blastocyst complementation experiment, a chimera developed spontaneous extragonadal malignant teratoma; southern blot analysis shows that the tumor is derived entirely from Hivep3 mutant ES cells

hematopoietic system

decreased double-positive T cell number ( J:79652 )

• in a Rag2-deficient blastocyst complementation experiment, chimeras show decreased numbers of CD4+CD8+ thymocytes by 6 months of age

limbs/digits/tail

polydactyly ( J:79652 )

• in a Rag2-deficient blastocyst complementation experiment, a chimera exhibited postaxial polydactyly in both paws

renal/urinary system

hydronephrosis ( J:79652 )

• in a Rag2-deficient blastocyst complementation experiment, a chimera developed dilation of pelvis and calyx of a kidney