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Targeted Allele Detail
Symbol: Nck1tm1Paw
Name: non-catalytic region of tyrosine kinase adaptor protein 1; targeted mutation, Tony Pawson
MGI ID: MGI:2667151
Synonyms: Nck1-, Nck1IRES-lacZ
Gene: Nck1  Location: Chr9:100494302-100546134 bp, - strand  Genetic Position: Chr9, 52.69 cM
Germline Transmission:  Earliest citation of germline transmission: J:83956
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsAn IRES-beta-galactosidase cassette was inserted into the first coding exon 29 nucleotides downstream from the start codon. This disrupts one of three SH3 domains. (J:83956)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 67 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nck1 Mutation:  23 strains or lines available
Original:  J:83956 Bladt F, et al., The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory