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Targeted Allele Detail
Symbol: Fcgr1tm1Jsv
Name: Fc receptor, IgG, high affinity I; targeted mutation 1, J Sjef Verbeek
MGI ID: MGI:2664927
Synonyms: FcgammaRI-, Fcgr1tm1Sjv
Gene: Fcgr1  Location: Chr3:96282909-96293969 bp, - strand  Genetic Position: Chr3, 41.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:83995
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe 3' part of the promoter, the exons encoding the L1 and L2 domains, and the 5' portion of the exon encoding the EC domain were deleted and replaced with a hygromycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of RNA from neutrophils, macrophages, and dendritic cells. (J:83995)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Fcgr1 Mutation:  9 strains or lines available
Original:  J:83995 Ioan-Facsinay A, et al., FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity. 2002 Mar;16(3):391-402
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory