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Psen2tm1Haa
Targeted Allele Detail
Nomenclature
Symbol: Psen2tm1Haa
Name: presenilin 2; targeted mutation 1, Christian Haass
MGI ID: MGI:2664242
Synonyms: PS2-
Gene: Psen2  Location: Chr1:180227004-180263438 bp, - strand  Genetic Position: Chr1, 84.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83860
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into exon 5 via homologous recombination. Absence of gene expression was confirmed by Northern and Western blot analysis of brain lysates from homozygous mutant animals. (J:83860)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psen2 Mutation:  5 strains or lines available
References
Original:  J:83860 Steiner H, et al., A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem. 1999 Oct 1;274(40):28669-73
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory