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Targeted Allele Detail
Symbol: Fkbp6tm1Pngr
Name: FK506 binding protein 6; targeted mutation 1, Josef M Penninger
MGI ID: MGI:2663987
Synonyms: Fkbp6-
Gene: Fkbp6  Location: Chr5:135291704-135350044 bp, - strand  Genetic Position: Chr5, 75.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:83634
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGenomic sequence encompassing a portion of exon 6 and all of exon 7 was replaced with a neo cassette inserted by homologous recombination. Neither transcript nor protein were detected in testes of homozygous mutant mice by Northern or Western blot analyses. (J:83634)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp6 Mutation:  4 strains or lines available
Original:  J:83634 Crackower MA, et al., Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science. 2003 May 23;300(5623):1291-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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