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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fkbp6tm1Pngr
targeted mutation 1, Josef M Penninger
MGI:2663987
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fkbp6tm1Pngr/Fkbp6tm1Pngr involves: 129P2/OlaHsd * C57BL/6 MGI:2664000


Genotype
MGI:2664000
hm1
Allelic
Composition		 Fkbp6tm1Pngr/Fkbp6tm1Pngr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkbp6tm1Pngr mutation (0 available); any Fkbp6 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:83634 )
• no spermatozoa were observed in the caudal epididymis or seminiferous tubules
abnormal spermatocyte morphology ( J:83634 )
• apoptosis of spermatocytes, most prevalent 21 days after birth
arrest of male meiosis ( J:83634 )
• arrest at pachytene stage
male infertility ( J:83634 )
• males are infertile; however, fertility and meiosis are normal in females and no alterations of hormone levels (testosterone, LH, FSH, or estradiol) were detected in male mice

endocrine/exocrine glands

cellular
azoospermia ( J:83634 )
• no spermatozoa were observed in the caudal epididymis or seminiferous tubules
abnormal spermatocyte morphology ( J:83634 )
• apoptosis of spermatocytes, most prevalent 21 days after birth




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory