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Ccn2tm1Kml
Targeted Allele Detail
Nomenclature
Symbol: Ccn2tm1Kml
Name: cellular communication network factor 2; targeted mutation 1, Karen M Lyons
MGI ID: MGI:2663631
Synonyms: Ccn2-, Crgf-, CTGFneo
Gene: Ccn2  Location: Chr10:24595442-24598683 bp, + strand  Genetic Position: Chr10, 11.84 cM, cytoband A3-B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83260
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by RT-PCR analysis. (J:83260)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 27 assay results
In Structures Affected by this Mutation: 30 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccn2 Mutation:  14 strains or lines available
References
Original:  J:83260 Ivkovic S, et al., Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development. 2003 Jun;130(12):2779-91
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory