Rtn4^{Gt(OST45048)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Rtn4^{Gt(OST45048)Lex}
• Name: reticulon 4; gene trap OST45048, Lexicon Genetics
• MGI ID: MGI:2661228
• Synonyms: nogo-A/B^-, nogo-ab^trap, Rtn4^{Gt(VICTR37)1Stmr}
• Gene: Rtn4 Location: Chr11:29642947-29694331 bp, + strand Genetic Position: Chr11, 16.79 cM
• Alliance: Rtn4^{Gt(OST45048)Lex} page

Mutation origin

• Mutant Cell Line: OST45048
• Germline Transmission: Earliest citation of germline transmission: J:83193
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Hypomorph, Modified isoform(s), Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector consisting of LTR sites flanking a beta-geo cassette containing a splice acceptor and a PGK-btk cassette containing a splice donor integrated into an exon specific for the A isoform. Northern and Western blot analyses of brain and lung tissue indicated an absence of transcript and protein corrsponding to isoforms A and B. (J:83193)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST45048	CG501280 ; (MGI Seq Detail)	3' RACE	Chr11:29683713-29692075 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  108 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtn4 Mutation: 130 strains or lines available

References

• Original: J:83193 Kim JE, et al., Axon regeneration in young adult mice lacking Nogo-A/B. Neuron. 2003 Apr 24;38(2):187-99
• All: 20 reference(s)