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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rtn4Gt(OST45048)Lex
gene trap OST45048, Lexicon Genetics
MGI:2661228
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rtn4Gt(OST45048)Lex/Rtn4Gt(OST45048)Lex involves: 129S5/SvEvBrd MGI:3575013
hm2
 		Rtn4Gt(OST45048)Lex/Rtn4Gt(OST45048)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:4353804


Genotype
MGI:3575013
hm1
Allelic
Composition		 Rtn4Gt(OST45048)Lex/Rtn4Gt(OST45048)Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4Gt(OST45048)Lex mutation (0 available); any Rtn4 mutation (130 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enhanced central nervous system regeneration ( J:83193 )
• enhanced spinal cord regeneration and locomotor recovery after injury, relative to controls




Genotype
MGI:4353804
hm2
Allelic
Composition		 Rtn4Gt(OST45048)Lex/Rtn4Gt(OST45048)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4Gt(OST45048)Lex mutation (0 available); any Rtn4 mutation (130 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:151085 )
N
• the enhanced spinal cord regeneration observed in a previous study (J:83193) was not observed in this study with the discrepancy attributed to mislabeling in the earlier study of central vs. peripheral neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory