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Rtn4tm1Matl
Targeted Allele Detail
Summary
Symbol: Rtn4tm1Matl
Name: reticulon 4; targeted mutation 1, Marc Tessier-Lavigne
MGI ID: MGI:2661136
Synonyms: Nogo-, Nogo-A/B, nogo-abatg
Gene: Rtn4  Location: Chr11:29642947-29694331 bp, + strand  Genetic Position: Chr11, 16.79 cM
Alliance: Rtn4tm1Matl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83192
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Modified isoform(s), Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding region of exon 1, which is specific to isoforms A and B (but not to isoform C), was replaced with a cassette containing IRES-GFPLacZ-loxP and an frt flanked hprt. Northern blot analysis of homozygous mutant brain tissue indicated an absence of A and B transcript and confirmed the presence of C transcript. The A and B isoforms were undetected by Western blot analysis. (J:83192)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rtn4 Mutation:  130 strains or lines available
References
Original:  J:83192 Zheng B, et al., Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron. 2003 Apr 24;38(2):213-24
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory