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Targeted Allele Detail
Symbol: Otx2tm6.1Asim
Name: orthodenticle homolog 2; targeted mutation 6.1, Antonio Simeone
MGI ID: MGI:2661067
Synonyms: Otx2-
Gene: Otx2  Location: Chr14:48657679-48667644 bp, - strand  Genetic Position: Chr14, 25.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:83110
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele is a derivative Otx2tm6Asim. The area contained between loxP sites, which include exon 2 and a PGK-neo cassette, was removed by crossing to Otx1tm4(cre)Asim. (J:83110)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  37 strains or lines available
Original:  J:83110 Puelles E, et al., Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci. 2003 May;6(5):453-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory