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Otx2tm6Asim
Targeted Allele Detail
Nomenclature
Symbol: Otx2tm6Asim
Name: orthodenticle homeobox 2; targeted mutation 6, Antonio Simeone
MGI ID: MGI:2661065
Synonyms: Otx2flox
Gene: Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83110
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA a single loxP site was inserted upstream of exon 2 and floxed PGK-neo was inserted downstream of exon 2 via homologous recombination. Cre-mediated recombination removed the selection cassette. (J:83110)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  45 strains or lines available
References
Original:  J:83110 Puelles E, et al., Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci. 2003 May;6(5):453-60
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory