About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Hyal1tm1Stn
Name: hyaluronoglucosaminidase 1; targeted mutation 1, Robert Stern
MGI ID: MGI:2658730
Gene: Hyal1  Location: Chr9:107576927-107581710 bp, + strand  Genetic Position: Chr9, 58.17 cM, cytoband F1-F2
Germline Transmission:  Earliest citation of germline transmission: J:136860
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA Neo cassette was inserted into exon 2, replacing nucleotides 6487518-6488270 of GenBank NT_039477.6. This replacement resulted in the deletion of nearly half of the coding region, 753 bp, and included a DWE amino acid sequence. Western blot analysis confirmed absence of protein and HA zymography of serum showed no detectable hyaluronidase activity in homozygotes. (J:136860)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hyal1 Mutation:  8 strains or lines available
MMRRC states the founder genetic background as 129P2/OlaHsd, however this has not been confirmed.

Original:  J:136860 Martin DC, et al., A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis. Hum Mol Genet. 2008 Jul 1;17(13):1904-15
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory