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Bcl2a1atm1Prys
Targeted Allele Detail
Nomenclature
Symbol: Bcl2a1atm1Prys
Name: B cell leukemia/lymphoma 2 related protein A1a; targeted mutation 1, Michael Prystowsky
MGI ID: MGI:2656326
Synonyms: A1-a-, Bcl2a1atm1Orlf
Gene: Bcl2a1a  Location: Chr9:88838973-88844469 bp, + strand  Genetic Position: Chr9, 47.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74478
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by RT-PCR analysis of bone marrow macrophage RNA from homozygous mutant animals. (J:74478)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2a1a Mutation:  10 strains or lines available
References
Original:  J:74478 Orlofsky A, et al., Deficiency in the Anti-Apoptotic Protein A1-a Results in a Diminished Acute Inflammatory Response. J Immunol. 2002 Feb 15;168(4):1840-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory