All Phenotypes Bcl2a1a<tm1Prys> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bcl2a1a^tm1Prys
targeted mutation 1, Michael Prystowsky
MGI:2656326

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl2a1a^tm1Prys/Bcl2a1a^tm1Prys	involves: 129/Sv * C57BL/6J * SJL	MGI:2656328

Allelic Composition	Bcl2a1a^tm1Prys/Bcl2a1a^tm1Prys
Genetic Background	involves: 129/Sv * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2a1a^tm1Prys mutation (1 available); any Bcl2a1a mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:74478 )

• mutants survive one day longer than wild-type after Toxoplasma gondii infection

immune system

abnormal neutrophil physiology ( J:74478 )

• sporadic increase in apoptosis in inflammatory neutrophils after Toxoplasma gondii infection

decreased inflammatory response ( J:74478 )

• inflammation in attenuated in response to Toxoplasma gondii infection

decreased susceptibility to parasitic infection ( J:74478 )

• peritoneal leukocytosis is decreased in Toxoplasma gondii infected mutants, however no differences in peritoneal parasite load is observed

hematopoietic system

abnormal neutrophil physiology ( J:74478 )

• sporadic increase in apoptosis in inflammatory neutrophils after Toxoplasma gondii infection

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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