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Fn1tm2Feb
Targeted Allele Detail
Nomenclature
Symbol: Fn1tm2Feb
Name: fibronectin 1; targeted mutation 2, Francisco E Baralle
MGI ID: MGI:2655542
Synonyms: EDA-, Eda-Fn-, Fn-EIIIA-
Gene: Fn1  Location: Chr1:71585520-71653200 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84274
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe floxed genomic fragment containing a modified EDA exon was excised from Fn1tm1Feb via in vivo cre mediated recombination in the germline. RNase protection and RT-PCR analysis showed that while transcripts encoding other isoforms were transcribed from the mutant allele, the EDA exon was constituitively excluded in homozygous mutant mice. (J:84274)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:  75 strains or lines available
References
Original:  J:84274 Muro AF, et al., Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan. J Cell Biol. 2003 Jul 7;162(1):149-60
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory