Phenotypes associated with this allele

• Allele Symbol: Fn1^tm2Feb
• Allele Name: targeted mutation 2, Francisco E Baralle
• Allele ID: MGI:2655542
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fn1^tm2Feb/Fn1^tm2Feb	involves: 129X1/SvJ	MGI:2668714

Genotype
MGI:2668714

hm1

• Allelic Composition: Fn1^tm2Feb/Fn1^tm2Feb
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84274 )

• homozygotes develop normally and are phenotypically indistinguishable from wild-type mice; however, 87.5% of them die by 30 months of age

• no significant reduction in survival is observed up to 15 months of age

homeostasis/metabolism

impaired wound healing ( J:84274 )

• at day 5 after full thickness cutaneous wounding, homozygotes display an abnormal healing process with abnormal reepithelization and edematous granulation tissue relative to wild-type mice

• at day 7 after wounding, homozygotes display a significantly higher fraction of ulcerated wounds than wild-type and Fn1^tm1Feb control mice (63% and 22%, respectively), along with a delay in reepithelization, an influx of polymorphonuclear leukocytes and macrophages, and a higher number of BrdU-positive cells in the edematous-like and ulcerative regions

integument

skin lesions ( J:84274 )

• upon postmortem examination, 20%-25% of homozygotes displayed various skin hyperproliferative and spontaneous ulcerative lesions on mid-dorsal skin; in contrast, <5% of wild-type mice and Fn1^tm1Feb homozygotes had any kind of skin lesions

spontaneous skin ulceration ( J:84274 )

• on mid-dorsal skin