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Tg(Lck-icre)3779Nik
Transgene Detail
Nomenclature
Symbol: Tg(Lck-icre)3779Nik
Name: transgene insertion 3779, Nigel Killeen
MGI ID: MGI:2655492
Synonyms: dLck-hcre3779, Tg(Lck-cre)3779Nik
Transgene: Tg(Lck-icre)3779Nik  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThis transgene expresses the codon-improved cre recombinase (icre) open reading frame under the control of the distal Lck promoter (dLck). This transgene is expressed in T cells primarily after Tcra locus rearrangement and the cells have reached the TCRhi stage of development. (J:73479, J:99042)
Recombinase
activity
Activity:
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Driver: Lck     Summary of all recombinase alleles driven by Lck.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
This transgene is used in J:73479, but specific details are published in J:99042.
References
Original:  J:73479 Wang Q, et al., Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene. J Exp Med. 2001 Dec 17;194(12):1721-30
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory