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Nodaltm1Hmd
Targeted Allele Detail
Nomenclature
Symbol: Nodaltm1Hmd
Name: nodal; targeted mutation 1, Hiroshi Hamada
MGI ID: MGI:2654943
Synonyms: Nodalneo
Gene: Nodal  Location: Chr10:61417972-61425338 bp, + strand  Genetic Position: Chr10, 32.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82703
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed PGK-neo cassette was inserted 5 kb upstream of the translation initiation site via homologous recombination, replacing a 0.7 kb region which contains the second left side-specific enhancer (LSE). The resulting allele is hypomorphic. (J:82703)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nodal Mutation:  18 strains or lines available
References
Original:  J:82703 Saijoh Y, et al., Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 2003 Apr 1;256(1):160-72
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory