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Targeted Allele Detail
Symbol: Nodaltm1Hmd
Name: nodal; targeted mutation 1, Hiroshi Hamada
MGI ID: MGI:2654943
Synonyms: Nodalneo
Gene: Nodal  Location: Chr10:61253751-61261117 bp, + strand  Genetic Position: Chr10, 32.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:82703
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Hypomorph, Modified regulatory region)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed PGK-neo cassette was inserted 5 kb upstream of the translation initiation site via homologous recombination, replacing a 0.7 kb region which contains the second left side-specific enhancer (LSE). The resulting allele is hypomorphic. (J:82703)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nodal Mutation:  38 strains or lines available
Original:  J:82703 Saijoh Y, et al., Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 2003 Apr 1;256(1):160-72
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory