Rag2^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Rag2^tm1Cgn
• Name: recombination activating gene 2; targeted mutation 1, University of Cologne
• MGI ID: MGI:2654906
• Synonyms: RAG-2^fl
• Gene: Rag2 Location: Chr2:101455063-101462874 bp, + strand Genetic Position: Chr2, 53.87 cM
• Alliance: Rag2^tm1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72214
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the coding region of the gene. The inserted sites had no effect on the normal function of the gene. (J:72214)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rag2 Mutation: 117 strains or lines available

References

• Original: J:72214 Hao Z, et al., Homeostasis of peripheral b cells in the absence of b cell influx from the bone marrow. J Exp Med. 2001 Oct 15;194(8):1151-64
• All: 41 reference(s)