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Targeted Allele Detail
Symbol: Robo1tm1Phr
Name: roundabout guidance receptor 1; targeted mutation 1, Pamela H Rabbitts
MGI ID: MGI:2654881
Synonyms: Dutt1/Robo1 -
Gene: Robo1  Location: Chr16:72308306-73046095 bp, + strand  Genetic Position: Chr16, 41.08 cM
Lung abnormalities of Robo1tm1Phr/Robo1tm1Phr mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:73485
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exon 2. Western blot analysis demonstrated that reduced levels of a mutant protein was made from this allele that lacked the Ig domain encoded by exon 2. (J:73485)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Robo1 Mutation:  8 strains or lines available
Original:  J:73485 Xian J, et al., Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15062-6
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory