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Targeted Allele Detail
Symbol: Kcnmb1tm1Pong
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 1; targeted mutation 1, Olaf Pongs
MGI ID: MGI:2654278
Synonyms: BKbeta1-
Gene: Kcnmb1  Location: Chr11:33963013-33973641 bp, + strand  Genetic Position: Chr11, 19.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:82471
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsGene targeting was used to flank exon 1 with a floxed PGK-neo cassette on one side and a loxP site on the other side. Correctly targeted ES cells were transiently transfected with a cre-recombinase plasmid to delete exon 1. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot and RT-PCR analysis. (J:82471)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnmb1 Mutation:  5 strains or lines available
Original:  J:82471 Pluger S, et al., Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure. Circ Res. 2000 Nov 24;87(11):E53-60
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory