Phenotypes associated with this allele

• Allele Symbol: Kcnmb1^tm1Pong
• Allele Name: targeted mutation 1, Olaf Pongs
• Allele ID: MGI:2654278
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnmb1^tm1Pong/Kcnmb1^tm1Pong	involves: 129S1/Sv * 129X1/SvJ	MGI:2654282

Genotype
MGI:2654282

hm1

• Allelic Composition: Kcnmb1^tm1Pong/Kcnmb1^tm1Pong
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased systemic arterial blood pressure ( J:82471 )

• higher systemic blood pressure but respond normally to alpha1-adrenergic vasoconstriction and nitric oxide-mediated vasodilation

abnormal vascular smooth muscle physiology ( J:82471 )

• spontaneous transient outward K⁺ current frequencies are reduced at physiological membrane potentials in smooth muscle cells of cerebral arteries indicating abnormal calcium spark/spontaneous transient outward K⁺ current coupling that is shifted to more depolarized potentials

increased vasoconstriction ( J:82471 )

• thoracic aortic rings from mutant mice respond to norepinephrine and elevated KCl with an increased vasoconstriction

muscle

abnormal vascular smooth muscle physiology ( J:82471 )

• spontaneous transient outward K⁺ current frequencies are reduced at physiological membrane potentials in smooth muscle cells of cerebral arteries indicating abnormal calcium spark/spontaneous transient outward K⁺ current coupling that is shifted to more depolarized potentials

increased vasoconstriction ( J:82471 )

• thoracic aortic rings from mutant mice respond to norepinephrine and elevated KCl with an increased vasoconstriction