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Hand2tm1Eno
Targeted Allele Detail
Nomenclature
Symbol: Hand2tm1Eno
Name: heart and neural crest derivatives expressed transcript 2; targeted mutation 1, Eric N Olson
MGI ID: MGI:2653307
Synonyms: BAenh-, Delta neoBAenh, Hand2BA
Gene: Hand2  Location: Chr8:57320983-57324633 bp, + strand  Genetic Position: Chr8, 29.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81764
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe branchial arch enhancer, a 754 bp region upstream of the endogenous gene, was deleted by homologous recombination followed by cre mediated excision. Whole mount in situ hybridization of homozygous mutant embyros showed a lack of endogenous transcript in the ventrolateral portions of the first and second branchial arches. (J:81764)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand2 Mutation:  2 strains or lines available
References
Original:  J:81764 Yanagisawa H, et al., Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development. Development. 2003 Mar;130(6):1069-78
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory