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Targeted Allele Detail
Symbol: Hand2tm1Eno
Name: heart and neural crest derivatives expressed 2; targeted mutation 1, Eric N Olson
MGI ID: MGI:2653307
Synonyms: BAenh-, Delta neoBAenh, Hand2BA
Gene: Hand2  Location: Chr8:57320983-57324517 bp, + strand  Genetic Position: Chr8, 29.8 cM
Germline Transmission:  Earliest citation of germline transmission: J:81764
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe branchial arch enhancer, a 754 bp region upstream of the endogenous gene, was deleted by homologous recombination followed by cre mediated excision. Whole mount in situ hybridization of homozygous mutant embyros showed a lack of endogenous transcript in the ventrolateral portions of the first and second branchial arches. (J:81764)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand2 Mutation:  1 strain or line available
Original:  J:81764 Yanagisawa H, et al., Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development. Development. 2003 Mar;130(6):1069-78
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory