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Targeted Allele Detail
Symbol: Ndntm1Alb
Name: necdin; targeted mutation 1, Arthur L Beaudet
MGI ID: MGI:2653065
Synonyms: deltaNdn, Ndn-
Gene: Ndn  Location: Chr7:62348277-62349928 bp, + strand  Genetic Position: Chr7, 34.36 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:55267
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA cassette containing sequence encoding beta-galactosidase and neo was inserted at the endogenous locus via homologous recombination. Transcript was undetected by Northern blot analysis of brain and liver tissue obtained from heterozygous male and female mice carrying a paternal mutant allele. (J:55267)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndn Mutation:  2 strains or lines available
Original:  J:55267 Tsai TF, et al., Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndrome [letter]. Nat Genet. 1999 May;22(1):15-6
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory