Phenotypes associated with this allele

• Allele Symbol: Ndn^tm1Alb
• Allele Name: targeted mutation 1, Arthur L Beaudet
• Allele ID: MGI:2653065
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndn^tm1Alb/Ndn^tm1Alb	involves: 129S7/SvEvBrd	MGI:2653069
ht2	Ndn^tm1Alb/Ndn^+	involves: 129S7/SvEvBrd	MGI:2653070

Genotype
MGI:2653069

hm1

• Allelic Composition: Ndn^tm1Alb/Ndn^tm1Alb
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:55267 )

• homozygotes are viable, fertile, and display normal growth curves and normal brain structure with no detectable pathological abnormalities in all major organs examined, except for a uterine inflammation, the significance of which is unknown

• importantly, homozygotes do not develop obesity up to 10 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Prader-Willi syndrome	DOID:11983	OMIM:176270	J:55267

Genotype
MGI:2653070

ht2

• Allelic Composition: Ndn^tm1Alb/Ndn⁺
• Genetic Background: involves: 129S7/SvEvBrd

normal phenotype

no abnormal phenotype detected ( J:55267 )

• heterozygotes carrying a paternally inherited allele are viable, fertile, and do not develop obesity up to 10 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Prader-Willi syndrome	DOID:11983	OMIM:176270	J:55267