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Targeted Allele Detail
Symbol: Epas1tm1Yfk
Name: endothelial PAS domain protein 1; targeted mutation 1, Yoshiaki Fujii-Kuriyama
MGI ID: MGI:2653011
Synonyms: HLFkd
Gene: Epas1  Location: Chr17:86753907-86833410 bp, + strand  Genetic Position: Chr17, 56.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:82257
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsThe 5' UTR was disrupted by the insertion of a floxed PGK-neo cassette into exon 1 by homologous recombination. Real-time quantitative PCR analsysis of homozygous mutant mice showed reduced levels of transcript ranging from 20% to 80% of wild-type levels, depending on the organ. (J:82257)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:  43 strains or lines available
Original:  J:82257 Morita M, et al., HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 2003 Mar 3;22(5):1134-46
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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