Phenotypes associated with this allele

• Allele Symbol: Epas1^tm1Yfk
• Allele Name: targeted mutation 1, Yoshiaki Fujii-Kuriyama
• Allele ID: MGI:2653011
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epas1^tm1Yfk/Epas1^tm1Yfk	involves: 129P2/OlaHsd * C57BL/6J	MGI:2653025

Genotype
MGI:2653025

hm1

• Allelic Composition: Epas1^tm1Yfk/Epas1^tm1Yfk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal physiological neovascularization ( J:82257 )

• in a model of retinopathy of prematurity (ROP), proliferative neovascularization is not induced in the retinas of mutants during normoxic conditions preceded by hyperoxic treatment

vision/eye

abnormal retina inner nuclear layer morphology ( J:82257 )

• during prolonged exposure to normoxia following hyperoxic treatment, retinas exhibit degeneration in the inner nuclear layer at P21 due to poor neovascularization

abnormal eye electrophysiology ( J:82257 )

• mutants subjected to the model of retinopathy of prematurity show a complete loss of b-wave and oscillatory potentials but have a normal a-wave amplitude in a single-flash electroretinogram (ERG)