Ikbkb^tm2.1Cgn
Targeted Allele Detail

Summary

• Symbol: Ikbkb^tm2.1Cgn
• Name: inhibitor of kappaB kinase beta; targeted mutation 2.1, University of Cologne
• MGI ID: MGI:2652652
• Synonyms: Ikbkb^tm1.1Mpa, Ikk2^D
• Gene: Ikbkb Location: Chr8:23149228-23196605 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
• Alliance: Ikbkb^tm2.1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77233
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A single loxP site was left in place of exons 6 and 7 after cre mediated recombination of loxP sites flanking loxP sites in the germline. Protein was undetected by Western blot analysis of MEFs and splenocytes obtained from homozygous mutant mice. (J:77233)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbkb Mutation: 54 strains or lines available

References

• Original: J:77233 Pasparakis M, et al., TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature. 2002 Jun 20;417(6891):861-6
• All: 6 reference(s)