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Targeted Allele Detail
Symbol: Ikbkbtm2.1Cgn
Name: inhibitor of kappaB kinase beta; targeted mutation 2.1, University of Cologne
MGI ID: MGI:2652652
Synonyms: Ikbkbtm1.1Mpa, Ikk2D
Gene: Ikbkb  Location: Chr8:22659212-22706589 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Germline Transmission:  Earliest citation of germline transmission: J:77233
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA single loxP site was left in place of exons 6 and 7 after cre mediated recombination of loxP sites flanking loxP sites in the germline. Protein was undetected by Western blot analysis of MEFs and splenocytes obtained from homozygous mutant mice. (J:77233)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  33 strains or lines available
Original:  J:77233 Pasparakis M, et al., TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature. 2002 Jun 20;417(6891):861-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory