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Txktm1Pls
Targeted Allele Detail
Nomenclature
Symbol: Txktm1Pls
Name: TXK tyrosine kinase; targeted mutation 1, Pamela L Schwartzberg
MGI ID: MGI:2652126
Synonyms: rlk-
Gene: Txk  Location: Chr5:72695978-72752777 bp, - strand  Genetic Position: Chr5, 38.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54449
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 6 was disrupted by the insertion of neo and multiple stop codons. Neither full length nor truncated protein products were detected by Western blot analyses of homozygous mutant lymphoid cell extracts. An splentocyte assay indicated an absence of endogenous kinase activity in homozygous mutant mice. (J:54449)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Txk Mutation:  12 strains or lines available
References
Original:  J:54449 Schaeffer EM, et al., Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science. 1999 Apr 23;284(5414):638-41
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory