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Krt17tm1Cou
Targeted Allele Detail
Nomenclature
Symbol: Krt17tm1Cou
Name: keratin 17; targeted mutation 1, Pierre A Coulombe
MGI ID: MGI:2651542
Synonyms: K17-
Gene: Krt17  Location: Chr11:100256217-100261029 bp, - strand  Genetic Position: Chr11, 63.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82089
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing the proximal promoter, all of exons 1 through 4, and a portion of exon 5 was replaced with a neomycin selection cassette. Northern blot, Western blot, and immunostaining analyses showed an absence of normal transcript and protein in homozygous mutant mice. (J:82089)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Krt17 Mutation:  21 strains or lines available
References
Original:  J:82089 McGowan KM, et al., Keratin 17 null mice exhibit age- and strain-dependent alopecia. Genes Dev. 2002 Jun 1;16(11):1412-22
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory