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Prkacbtm2Gsm
Targeted Allele Detail
Nomenclature
Symbol: Prkacbtm2Gsm
Name: protein kinase, cAMP dependent, catalytic, beta; targeted mutation 2, G Stanley McKnight
MGI ID: MGI:2651519
Synonyms: C beta all-
Gene: Prkacb  Location: Chr3:146729579-146812946 bp, - strand  Genetic Position: Chr3, 72.28 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78451
Parent Cell Line:  REK2 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis indicated an absence of all three isoforms in homozygous mutant mice. (J:78451)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkacb Mutation:  17 strains or lines available
References
Original:  J:78451 Howe DG, et al., Molecular and Behavioral Effects of a Null Mutation in All PKA Cbeta Isoforms. Mol Cell Neurosci. 2002 Jul;20(3):515-24
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory