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Targeted Allele Detail
Symbol: Pde4dtm2Mct
Name: phosphodiesterase 4D, cAMP specific; targeted mutation 2, Marco Conti
MGI ID: MGI:2451182
Gene: Pde4d  Location: Chr13:108654177-109955969 bp, + strand  Genetic Position: Chr13, 59.69 cM
Germline Transmission:  Earliest citation of germline transmission: J:58116
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsThis allele differs from Pde4dtm1Mct in that the PGK-hprt cassette inserted by homologous recombination to replace exons 8 and 9 was inserted in the same orientation as the endogenous locus. (Corrected information communicated to MGI by author.) (J:58116)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde4d Mutation:  118 strains or lines available
Phenotypic analysis of this allele served to rule out spurious rearrangements at the site of recombination in Pde4dtm1Mct
Original:  J:58116 Jin SL, et al., Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11998-2003
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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