Pde4d^tm2Mct
Targeted Allele Detail

Summary

• Symbol: Pde4d^tm2Mct
• Name: phosphodiesterase 4D, cAMP specific; targeted mutation 2, Marco Conti
• MGI ID: MGI:2451182
• Gene: Pde4d Location: Chr13:108790711-110092503 bp, + strand Genetic Position: Chr13, 59.69 cM
• Alliance: Pde4d^tm2Mct page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58116
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: This allele differs from Pde4d^tm1Mct in that the PGK-hprt cassette inserted by homologous recombination to replace exons 8 and 9 was inserted in the same orientation as the endogenous locus. (Corrected information communicated to MGI by author.) (J:58116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde4d Mutation: 181 strains or lines available

Notes

Phenotypic analysis of this allele served to rule out spurious rearrangements at the site of recombination in Pde4d^tm1Mct

References

• Original: J:58116 Jin SL, et al., Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11998-2003
• All: 1 reference(s)