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Targeted Allele Detail
Symbol: Pde4dtm1Mct
Name: phosphodiesterase 4D, cAMP specific; targeted mutation 1, Marco Conti
MGI ID: MGI:2451168
Synonyms: 4DKO, PDE4D-
Gene: Pde4d  Location: Chr13:108654177-109955969 bp, + strand  Genetic Position: Chr13, 59.69 cM
Growth comparison of wild type and Pde4dtm1Mct/Pde4dtm1Mct mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:58116
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.2 kb fragment encompassing exons 8 and 9 was replaced with a PGK-hrpt cassette inserted in the opposite orientation by homologous recombination. The deleted region encoded the catalytic domain. Neither transcript nor protein was detected in homozygous mutant brain tissue by Northern and Western blot analyses. (Corrected information communicated to MGI by author.) (J:58116)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Pde4d Mutation:  118 strains or lines available
Original:  J:58116 Jin SL, et al., Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11998-2003
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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