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Tab2tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Tab2tm1Aki
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2; targeted mutation, Shizuo Akira
MGI ID: MGI:2450936
Synonyms: TAB2-
Gene: Tab2  Location: Chr10:7905653-7956230 bp, - strand  Genetic Position: Chr10, 2.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81816
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsFlanking loxP sites were introduced to the large exon and a floxed neo cassette was inserted into the upstream intron. Transient expression of cre recombinase in correctly targeted ES cells resulted in deletion of the floxed neo cassette leaving behind loxP sites flanking the large exon. Mutant animals were then mated to cre deleter strain Tg(ACTB-cre)13Miya to generate null animals. (J:81816)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tab2 Mutation:  17 strains or lines available
References
Original:  J:81816 Sanjo H, et al., TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling. Mol Cell Biol. 2003 Feb;23(4):1231-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory