Phenotypes associated with this allele

• Allele Symbol: Tab2^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:2450936
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tab2^tm1Aki/Tab2^tm1Aki	involves: 129P2/OlaHsd * C57BL/6	MGI:2450945
ht2	Tab2^tm1Aki/Tab2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3511666

Genotype
MGI:2450945

hm1

• Allelic Composition: Tab2^tm1Aki/Tab2^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:81816 )

• embyros were viable up to day E11.5

cardiovascular system

liver hemorrhage ( J:81816 )

• severe hemorrhage of the liver at E12.5

liver/biliary system

liver hemorrhage ( J:81816 )

• severe hemorrhage of the liver at E12.5

abnormal hepatocyte morphology ( J:81816 )

• elevated number of apoptotic liver cells

integument

pallor ( J:81816 )

• embryos appeared pale and anemic

Genotype
MGI:3511666

ht2

• Allelic Composition: Tab2^tm1Aki/Tab2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:81816 )

• incomplete penetrance; 70% of animals die within a week